Organ Bio Assemble
OBA Laboratory
Organ Engineering
Organ engineering can deliver the gift of life to people and help solve the problems facing our Earth with utilising the principles of fluid mechanics.
Hiroki Bochimoto, Nur Khatijah Mohd Zin, Yo Ishihara, Tetsuya Nakajo,Hiromichi Obara,Naoto Matsuno, Daisuke Kondoh Ultrastructural configuration of porcine liver preserved by machine perfusion versus static cold storage donated cardiac after death Tissue and Cell 2025 in press,10.1016/j.tice.2025.103262
Fernanda W. Fernandes,Fatma Selin Yildirim,Hiroshi Horie,Omer F. Karakaya,Chunbao Jiao,Geofia S. Crasta,Nasim Eshraghi,Koki Takase,Tobias Diwan,Laura Batista de Oliveira,Charles Miller,Chase J. Wehrle,Sangeeta Satish,Keyue Sun,Naoto Matsuno , Andrea Schlegel Beyond Static Cold Storage: Toward the Next Generation of Tailored Organ Preservation Solutions Int. J. Mol. Sci 2025 26(19), 9515 , 10.3390/ijms26199515 10.3390/ijms26199515
Satoshi Muto, Hiromichi Obara, Mio Takashima, Daisuke Ishii, Seisuke Sakamoto, Naoto Matsuno Evaluation of the Small Intestinal Functions Using the Extracorporeal Small Intestinal Serosa Voltage Measurement Method , IEEE Access 2025 Vol.13, 178981-178992 , 10.1109/ACCESS.2025.3617925 10.1109/ACCESS.2025.3617925
Soichiro Ueno, Daisuke Kawashima, Katsuhiro Matsuura, Hiromichi Obara, Ryou Tanaka, Masahiro Takei Real-time prediction of heparin concentration in blood extracorporeal circulation by relaxation time distribution (RTD) Bioelectrochemistry 2025 Vol.163 , 10.1016/j.bioelechem.2025.108912
Hiroyoshi Iwata, Hiromichi Obara, Tetsuya Nakajo, Hiroki Kaneko, Yuga Okazawa,Nur Khatijah Mohd Zin, Hiroki Bochimoto, Makito Ohashi, Yoko Kawada, Mizuho Ohara,Hideki Yokoo, Naoto Matsuno Beneficial Effects of Combined Use of Extracorporeal Membrane Oxygenation and Hypothermic Machine Perfusion in Porcine Donors after Cardiac Death for Liver Transplantation , Journal of Clinical Medicine 2023 Vol.12(18):6031 , 10.3390/jcm12186031
Nur Khatijah Mohd Zin, Hiroki Bochimoto, Daisuke Kondoh, Yo Ishihara, Hiroyoshi Iwata, Tatsuya Shonaka, Hiromichi Obara, Hiromi Sakai, Hiroyuki Furukawa, Naoto Matsuno Machine perfusion preservation with hemoglobin based oxygen vesicles alleviate ultrastructural damages in porcine liver donated after cardiac death , Microscopy Research and Technique 2023 Vol.86(12):1725-1732. , 10.1002/jemt.24405
Nguyen Van Lap, Akari Misawa, Hiromichi Obara An electrical analog permeability model assessing fluid flow in a decellularized organ , Computer Methods and Programs in Biomedicine 2023 Vol.237, 107595 , 10.1016/j.cmpb.2023.107595
Van Lap Nguyen,Hiromichi Obara Numerical assessment of recellularization conditions to vessel occlusion , Biomechanics and Modeling in Mechanobiology 2023 Vol.22(1), 1035?1047 , 10.1007/s10237-023-01699-1
Hiroyoshi Iwata, Tetsuya Nakajo, Hiroki Kaneko, Yuga Okazawa, Nur Khatijah Mohd Zin, Hiroki Bochimoto, Makito Ohashi, Yoko Kawada, Shota Kamikawa, Takahiro Kudo, Yoko Okada, Mizuho Ohara, Hiromichi Obara, Naoto Matsuno Combined Use of Subnormothermic Extracorporeal Support and Hypothermic Oxygenated Machine Perfusion for Liver Graft After Cardiac Death in Pigs , Transplantation Proceedings 2023 Vol.55(4),1021-1026 , 10.1016/j.transproceed.2023.03.013
Hiroyoshi Iwata, Naoto Matsuno, Daisuke Ishii, Asuka Toriumi, Masahide Otani, Mizuho Ohara, Hiromichi Obara, Yuji Nishikawa, Hideki Yokoo Applicability of the histidine?tryptophan?ketoglutarate solution as a machine perfusion solution for marginal liver grafts , Journal of Gastroenterology and Hepatology 2023 Vol.38(5),783-790 , 10.1111/jgh.16140
Daisuke Kawashima, Hiromichi Obara, MasahiroTakei Multiple regression fitting electrical impedance spectro-tomography for quantitative image reconstruction of dead cell fraction and cell concentration , IEEE Open Journal of Instrumentation & Measurement 2022 Vol.1,1-8 , 10.1109/OJIM.2022.3198476
WeijunZhu, HiromichiObara The pre-shearing effect on rheological properties of okra mucilage , Colloids and Surfaces A: Physicochemical and Engineering Aspects 2022 Vol.648,129257 , 10.1016/j.colsurfa.2022.129257
Hiroki Bochimoto, Yo Ishihara, Nur Khatijah Mohd Zin, Hiroyoshi Iwata, Daisuke Kondoh, Hiromichi Obara and Naoto Matsuno Ultrastructural Changes in Porcine Liver Sinusoidal Endothelial Cells of Machine Perfused Liver Graft Donated after Cardiac Death , WORLD JOURNAL OF GASTROENTEROLOGY 2022 28(19):2100-2111 10.3748/wjg.v28.i19.2100.
Songshi Li, Daisuke Kawashima, Michiko Sugawara, Hiromichi Obara, Kennedy Omondi Okeyo, Masahiro Takei Study of Transmembrane Ion Transport under Tonicity Imbalance using A Combination of Low Frequency-Electrical Impedance Spectroscopy (LF-EIS) and Improved Ion Transport Mode , Biomed Phys Eng Express 2022 Vol.8(3) 10.1088/2057-1976/ac5fc5
Rei EBIHARA, Tomoki MORIKAWA, Hiromichi OBARA Formation of Stratified Flow in Liquid-Liquid Two-Phase Flow of Water-Perfluorocarbon System in a Horizontal Pipe(in Japanese) , JAPANESE JOURNAL OF MULTIPHASE FLOW 2022 Vol.36(1),55-62 10.3811/jjmf.2022.003
松野 直徒,小原 弘道 臓器保存学を我が国に取り戻すために , Organ Biology 2022 Vol.29,No.2p.144-148 10.11378/organbio.29.144
Van Lap Nguyen, Hiromichi Obara Investigation of vessel occlusion during cell seeding process , Biomechanics and Modeling in Mechanobiology 2021 Vol.20, 2437?2450 10.1007/s10237-021-01517-6
Martin Wekesa Sifuna; Daisuke Kawashima; Katsuhiro Matsuura; Hiromichi Obara; Yusuke Nakajima; Masahiro Takei Simultaneous Electrical Online Estimation of Changes in Blood Hematocrit and Temperature in Cardiopulmonary Bypass , Journal of Artificial Organs 2022 Vol.25(4),305-313 10.1007/s10047-022-01320-9
Daisuke Ishii, Naoto Matsuno, Mikako Gochi, Hiroyoshi Iwata, Tatsuya Shonaka, Yuji Nishikawa, Hiromichi Obara, Hideki Yokoo, Hiroyuki Furukawa Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia-reperfusion injury , Scientific Reports 2021 Vol.19;11(1):22608 10.1038/s41598-021-01467-0
An Zhang; Daisuke Kawashima; Hiromichi Obara; Masahiro Takei Boundary Reflection Derivation Method Based on GHz Electrical Impedance Spectroscopy-Dielectric Properties Extraction Model (GHz EIS-DPEM) in Cell Solutions , IEEE Transactions on Microwave Theory and Techniques 2021 Vol.69(11), 4678 - 4688 10.1109/TMTT.2021.3105437
An Zhang,Daisuke Kawashima, Hiromichi Obara, Masahiro Takei Extraction Method of Cell's Complex Permittivity in Cell Solutions from Measured Impedance by GHz Electrical Impedance Spectroscopy , IEEE Sensors Journal 2021 Vol.21(3), 2505 - 2516 10.1109/JSEN.2020.3023912
Daisuke Kawashima, Songshi Li, Hiromichi Obara, Masahiro Takei Low-frequency Impedance-Based Cell Discrimination considering Ion Transport Model in Cell Suspension , IEEE Transactions on Biomedical Engineering 2020 Vol.68(3) 10.1109/TBME.2020.3002980
Yo Ishihara, Hiroki Bochimoto, Daisuke Kondoh, Hiromichi Obara and Naoto Matsuno The ultrastructural characteristics of bile canaliculus in porcine liver donated after cardiac death and machine perfusion preservation. , Plos One 2020 15(5): e0233917. 10.1371/journal.pone.0233917
An Zhang, Daisuke Kawashima, Hiromichi Obara, Masahiro Takei Analysis of influence of fibrinogen concentration on blood dielectric properties by GHz electrical impedance spectroscopy , Journal of Biorheology 2020 34(1):38-46 10.17106/jbr.34.38
Nguyen Ngoc Minh, Hiromichi Obara Effect of pH on the viscosity and viscoelastic properties of bile , "
Journal of Biorheology" 2020 34(1):30-37 10.17106/jbr.34.30
Nguyen Ngoc Minh, Hiromichi Obara Porcine Bile Viscosity Is Proportional to Density , Biorheology 2020 vol. 57, no. 1, pp. 27-36, 10.3233/BIR-190238
Tran, A.K., Kawashima, D., Sugarawa, M.,Obara, H., Okeyo, K.O., Takei, M Development of a noise elimination electrical impedance spectroscopy (neEIS) system for single cell identification , Sensing and Bio-Sensing Research 2020 Vol. 30, 100381 10.1016/j.sbsr.2020.100381
Ishii D, Matsuno N, Gochi M, Otani M, Shonaka T, Takahashi H, Nishikawa Y, Yoshikawa R, Obara H, Miyamoto K, Furukawa H Applicability of hypothermic oxygenate machine perfusion preservation for split-liver transplantation in a porcine model: An experimental study , Annals of Transplantation 2020 Vol.25:e919920 10.12659/AOT.919920
Kanazawa, H., Obara, H., Yoshikawa, R., (...), Nishikawa, Y., Matsuno, N. Impact of Machine Perfusion on Sinusoid Microcirculation of Liver Graft Donated After Cardiac Death , Journal of Surgical Research 2020 Vol.245, pp. 410-419
Hiromichi Obara,, Noriyuki Morito, Naoto Matsuno,(...), Hirano, T., Enosawa, S. Initial perfusate purification during subnormothermic machine perfusion for porcine liver donated after cardiac death , Journal of Artificial Organs 2020 Vol.23(1):62-69 10.1007/s10047-019-01123-5
Tatsuya Shonaka,Naoto Matsuno ,Hiromichi Obara,Ryo Yoshikawa,Yuji Nishikawa,Yo Ishihara,Hiroki Bochimoto,Mikako Gochi,Masahide Otani,Hiroyuki Kanazawa,Hiroshi Azuma,Hiromi Sakai,Hiroyuki Furukawa "Impact of human-derived hemoglobin based oxygen vesicles as a machine perfusion
solution for liver donation after cardiac death in a pig model" , Plos one 2019 Vol.14(12):e0226183 10.1371/journal.pone.0226183
Minh NN, Obara H, Shimokasa K, Zhu J Tensile behavior and extensional viscosity of bile. , Biorheology 2019 Vol.56(4):237-252 10.3233/BIR-190216
X.Liu, Y.Cui, T.Zhao, D.Kawashima, H.Obara, M.Takei Quantitative Detection of Living Yeast Fraction from Mixed Living and Dead Cell Solution by Micro Electrical Impedance Spectroscopy , IEEE Acsess 2019 Vol.7,pp33970 - 33977 10.1109/ACCESS.2019.2902576
X. Liu, J. Yao, T. Zhao, H. Obara, Y. Cui, M. Takei Image Reconstruction under Contact Impedance Effect in Micro Electrical Impedance Tomography Sensors , IEEE Transactions on Biomedical Circuits and Systems 2018 Vol.12(3),623-631 10.1109/TBCAS.2018.2816946
International conferences 2025
[Invited]Progress of clinical use of machine perfusion and organ preservation solution based on basic research , Naoto Matsuno , International Society for Organ Donation Professionals(ISODP) 2025 , 2025/12/3-6 , Kyoto, Japan
Small intestinal ischemia/reperfusion injury prediction during the subnormothermic machine perfusion focusing on the electrogastroenterogram , Satoshi Muto,Hiromichi Obara, Daisuke Ishii, Yuga Okazawa, Mio Takashima, Taiki Mori, Masafumi Furukawa, Tomoki Abe, Hiroki Kaneko, Shohei Ishizawa, Shotaro Iino, Seisuke Sakamoto, Naoto Matsuno , International Society for Organ Donation Professionals(ISODP) 2025 , 2025/12/3-6 , Kyoto, Japan
Integrated assessment of DCD liver during hypothermic oxygenated machine perfusion with fluorescence-based quantification , Taiki Mori,Hiromichi Obara, Yuga okazawa, Mio Takashima, Satoshi Muto, Masafumi Furukawa, Tomoki Abe, Hiroki Kaneko, Syotaro Ino, Toshitaka Yasuda, Shuta Kato, Seisuke Sakamoto, Naoto Matsuno , International Society for Organ Donation Professionals(ISODP) 2025 , 2025/12/3-6 , Kyoto, Japan
Effect of Hypothermic Machine Perfusion of the small intestine assessed by serosal electrical potential and peristalsis , Mio Takashima,Hiromichi Obara, Daisuke Ishii, Yuga Okazawa, Satoshi Muto, Taiki Mori, Masafumi Furukawa, Tomoki Abe, Hiroki Kaneko, Shohei Ishizawa, Shotaro Iino, Seisuke Sakamoto, Naoto Matsuno , International Society for Organ Donation Professionals(ISODP) 2025 , 2025/12/3-6 , Kyoto, Japan
Development of compact and transportable hypothermic machine perfusion system for marginal kidney donors , Masafumi Furukawa,Hiromichi Obara, Yuga okazawa, Mio Takashima, Satoshi Muto, Taiki Mori, Tomoki Abe, Makoto Kimura, Munehide Nakatugawa, Hitoshi Iwamoto, Hiroki Kaneko, Syunpei Ishizawa, Syotaro Ino, Seisuke Sakamoto, Naoto Matsuno , International Society for Organ Donation Professionals(ISODP) 2025 , 2025/12/3-6 , Kyoto, Japan
Quantification of Renal Oxygen Consumption During Hypothermic Oxygenated Perfusion (HOPE) , Tomoki Abe, Hiromichi Obara, Masafumi Furukawa, Takayoshi Shirakura,Satoshi Muto, Taiki Mori, Makoto Kimura, Hitoshi Iwamoto,Seisuke Sakamoto, Naoto Matsuno , International Federation for Artificial Organs(IFAO)2025 , 2025/11/19-21 , Chiba,Japan
Integrated assessment method of ischemic reperfusion injury during machine perfusion for DCD donor transplantation , Hiromichi Obara, Taiki Mori, Satoshi Muto, Toranosuke Nagasawa,Mio Takashima1, Masafumi Furukawa, Tomoki Abe, Hiroki Kaneko, Shotaro Iino, Seisuke Sakamoto, Naoto Matsuno , International Federation for Artificial Organs(IFAO)2025 , 2025/11/19-21 , Chiba,Japan
Small intestinal metabolism maintenance using subnormothermic machine perfusion for transplantation , Satoshi Muto, Hiromichi Obara, Daisuke Ishii, Mio Takashima, Taiki Mori, Masafumi Furukawa, Hiroki Kaneko, Shotaro Iino, Seisuke Sakamoto, Naoto Matsuno , International Federation for Artificial Organs(IFAO)2025 , 2025/11/19-21 , Chiba,Japan
Numerical and experimental analysis of vessel occlusion to evaluate optimal cell injection methods , Yoshiki Motegi,Akari Misawa,Van Lap Ngyen,Hiromichi Obara , 18th CTRMS(Cell Transplant and Regenerative Medicine Society)2025 , 2025/10/22-25 , Tokyo,Japan
Continuous Production of ECM with high-pressure homogenizer for Organ Engineering , Hiromichi Obara, Yoshiki Motegi , Shingo Seki , Yuya Tabata ,Mitsuyuki Tsurumi, Miwako Saka, Keiichiro Sawano, Wataru Sakurai , 18th CTRMS(Cell Transplant and Regenerative Medicine Society)2025 , 2025/10/22-25 , Tokyo,Japan
Assessment of Liver Functions with Integrated Fluorescence Measurement during Hypothermic Oxygenated Machine Perfusion , T. Mori , Y. Okazawa , H. Obara, T. Nakajo, H. Kaneko, S. Ino , H. Bochimoto, S. Sakamoto, M. Kasahara , N. Matsuno , ILTS(International Liver Transplantation Society)2025 , 2025/5/25-28 , Singapore,Singapore